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Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model Biocell
Fontana,Vanina Andrea; Sanchez,Melisa; Cebral,Elisa; Calvo,Juan Carlos.
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Embryo implantation; Placenta; Extracellular matrix.
Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000100005
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